InterPro domain: IPR040040

Autophagy-related protein 11 (ATG11; also known as cytoplasm to vacuole targeting protein 9) is required for transport of proteins from the cytosol to the vacuole [ 1 , 2 ], including whole mitochondria for autophagic digestion (mitophagy) in the autophagosome during starvation [ 3 ]. It also acts as the scaffold that recruit ATG proteins to the pre-autophagosome [ 4 ]. The orthologue in mammals is known as RB1-inducible coiled-coil protein 1 (RB1CC1) [ 5 ]; the orthologue in Schizosaccharomyces pombe is Taz1-interacting factor 1 (taf1) [ 6 ].

1. Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev. Cell 3, 825-37
2. Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway. Mol. Biol. Cell 16, 1593-605
3. Mitophagy in yeast occurs through a selective mechanism. J. Biol. Chem. 283, 32386-93
4. Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast. J. Cell Biol. 175, 925-35
5. p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200. Cell Cycle 10, 2763-9
6. Schizosaccharomyces pombe taf1+ is required for nitrogen starvation-induced sexual development and for entering the dormant GO state. Curr. Genet. 38, 307-13