InterPro domain: IPR040039

General Information

  • Identifier IPR040039
  • Description Phosphatidylinositol-glycan biosynthesis class X protein
  • Number of genes 145
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006506  

Abstract

PIG-X is an essential component of glycosylphosphatidylinositol-mannosyltransferase I [ 1 ]. It probably acts by stabilizing the mannosyltransferase PIG-M [ 2 ]. It has also be shown to interact with reticulocalbin 1 (RCN1) and reticulocalbin 2 (RCN2), and may negatively regulate the expression of these two genes [ 2 ].


1. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. Mol. Biol. Cell 16, 1439-48
2. Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors. Int. J. Oncol. 49, 868-76

Species distribution

Gene table