InterPro domain: IPR040038

Proteins in this family contain a domain found in yeast chromosome segregation in meiosis protein 3. Proteins include:

• Chromosome segregation in meiosis protein 3, which is required for required for chromosome segregation during meiosis and DNA damage repair, forming a fork protection complex with TOF1 [ 1 , 2 ].
• TIMELESS-interacting protein (also known as TIPIN), which is a nuclear protein that associates with the replicative helicase, and is required for efficient cell cycle arrest in response to DNA damage. It forms a checkpoint complex with TIMELESS [ 3 ].
• Protein TIPIN homolog, which is the orthologue of TIPIN from Caenorhabditis elegans and Drosophila melanogaster.
• Swi1-interacting protein swi3, from Schizosaccharomyces pombe, which forms a fork protection complex with swi1 [ 4 ].

1. Identification of protein complexes required for efficient sister chromatid cohesion. Mol. Biol. Cell 15, 1736-45
2. Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex. J. Mol. Biol. 347, 509-21
3. Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. Proc. Natl. Acad. Sci. U.S.A. 103, 18143-7
4. Swi1 and Swi3 are components of a replication fork protection complex in fission yeast. Mol. Cell. Biol. 24, 8342-55