InterPro domain: IPR040036

CYCLOPS (also known as IPD3) is required for root symbiosis with mycorrhizal fungi in plants [ 1 , 2 ]. It forms a signal transduction complex with CCaMK that is specifically required for symbiotic infection [ 3 ]. CYCLOPS binds to a motif within the ERN1 promoter and in combination with CCaMK positively regulates transcription of ERN1, a gene that encodes an AP2/ERF transcription factor [ 4 ].

1. OsIPD3, an ortholog of the Medicago truncatula DMI3 interacting protein IPD3, is required for mycorrhizal symbiosis in rice. New Phytol. 180, 311-5
2. Tomato CYCLOPS/IPD3 is required for mycorrhizal symbiosis but not tolerance to Fusarium wilt in mycorrhiza-deficient tomato mutant rmc. Mycorrhiza 215, 323-337
3. CYCLOPS, a mediator of symbiotic intracellular accommodation. Proc. Natl. Acad. Sci. U.S.A. 105, 20540-5
4. The ERN1 transcription factor gene is a target of the CCaMK/CYCLOPS complex and controls rhizobial infection in Lotus japonicus. New Phytol.