InterPro domain: IPR040023
General Information
- Identifier IPR040023
- Description WW domain-binding protein 4
- Number of genes 106
- Gene duplication stats Loading...
- Associated GO terms GO:0000398
Abstract
WW domain-binding protein 4 (WBP4; also known as formin-binding protein 21) is a component of the spliceosome, which is involved in pre-mRNA splicing. It contains a matrin-type zinc finger and two tandem WW domains. It interacts with the splicing factor SIPP1, and its binding and activation of pre-mRNA splicing depend on the WW domains [ 1 ]. This entry also includes zinc finger protein ZOP1 from Arabidopsis thaliana, which is also a pre-mRNA splicing factor that associates with several typical components of the splicing machinery and promotes Pol IV-dependent siRNA accumulation, DNA methylation, and transcriptional silencing [ 2 ].
1. Structure and Function of the Two Tandem WW Domains of the Pre-mRNA Splicing Factor FBP21 (Formin-binding Protein 21). J. Biol. Chem. 284, 25375-87
2. The splicing machinery promotes RNA-directed DNA methylation and transcriptional silencing in Arabidopsis. EMBO J. 32, 1128-40