InterPro domain: IPR040018

Exportin-5 mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos) [ 1 ]. Exportin-5 yeast homologue, also known as Msn5, is involved in nuclear import of replication protein A and export of Far1 and transcription factors Swi5, Swi6, Msn2, and Pho4 [ 2 , 3 , 4 ]. Its Arabidopsis homologue, HASTY 1, is involved in the nuclear export of microRNAs (miRNAs) [ 5 ].

1. Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins. J. Cell Biol. 156, 53-64
2. The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins. J. Cell Biol. 152, 729-40
3. Cell cycle activation of the Swi6p transcription factor is linked to nucleocytoplasmic shuttling. Mol. Cell. Biol. 23, 3126-40
4. Regulation of cell cycle transcription factor Swi5 by karyopherin Msn5. Biochim. Biophys. Acta 1823, 959-70
5. Nuclear processing and export of microRNAs in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 102, 3691-6