InterPro domain: IPR040017
General Information
- Identifier IPR040017
- Description Exportin-T
- Number of genes 134
- Gene duplication stats Loading...
- Associated GO terms GO:0006409 GO:0031267 GO:0000049 GO:0071528
Abstract
Exportin-T mediates the nuclear export of aminoacylated tRNAs [ 1 ]. Its budding yeast homologue, known as Los1, is involved in nuclear export of pre-tRNA and in re-export of mature tRNAs [ 2 ]. It binds to RanGTP and mature tRNAs cooperatively to form a nuclear export complex [ 3 ].
1. Identification of a tRNA-specific nuclear export receptor. Mol. Cell 1, 359-69
2. Regulation of tRNA bidirectional nuclear-cytoplasmic trafficking in Saccharomyces cerevisiae. Mol. Biol. Cell 21, 639-49
3. Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. Mol. Cell. Biol. 22, 5708-20
Species distribution
Gene table
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