InterPro domain: IPR040017

General Information

  • Identifier IPR040017
  • Description Exportin-T

Abstract

Exportin-T mediates the nuclear export of aminoacylated tRNAs [ 1 ]. Its budding yeast homologue, known as Los1, is involved in nuclear export of pre-tRNA and in re-export of mature tRNAs [ 2 ]. It binds to RanGTP and mature tRNAs cooperatively to form a nuclear export complex [ 3 ].


1. Identification of a tRNA-specific nuclear export receptor. Mol. Cell 1, 359-69
2. Regulation of tRNA bidirectional nuclear-cytoplasmic trafficking in Saccharomyces cerevisiae. Mol. Biol. Cell 21, 639-49
3. Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. Mol. Cell. Biol. 22, 5708-20

Species distribution

Gene table