InterPro domain: IPR040015

Proteins in this entry possess a ubiquitin-2 like Rad60 SUMO-like domain. These ubiquitin-fold proteins are plasma membrane-anchored by prenylation [ 1 ]. Proteins include mammalian ubiquitin-like protein 3, which has a ubiquitous distribution [ 2 ], and plant membrane-anchored ubiquitin-fold proteins 1 to 6, which, in Arabidopsis, recruit and dock specific E2 ubiquitin-conjugating enzymes to the plasma membrane. They appear to interact noncovalently with an E2 surface opposite the active site that forms a covalent linkage with Ub [ 3 ]. This entry also includes uncharacterised proteins from fungi.

1. MUBs, a family of ubiquitin-fold proteins that are plasma membrane-anchored by prenylation. J. Biol. Chem. 281, 27145-57
2. Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene. Gene 233, 189-95
3. Arabidopsis membrane-anchored ubiquitin-fold (MUB) proteins localize a specific subset of ubiquitin-conjugating (E2) enzymes to the plasma membrane. J. Biol. Chem. 286, 14913-21