InterPro domain: IPR039948

Elongin-C is a highly conserved protein found in a variety of multiprotein complexes in human, rat, fly, worm, and yeast cells [ 1 ]. Budding yeast elongin-C homologue, Elc1, forms a complex with Cul3 that is required for Pol II polyubiquitylation and degradation [ 2 ]. Elc1 also plays a role in global genomic repair [ 3 ]. In humans, elongin-C works as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL) [ 4 ].

1. Binding to Elongin C inhibits degradation of interacting proteins in yeast. J. Biol. Chem. 277, 15586-91
2. ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells. Mol. Cell. Biol. 27, 3211-6
3. Yeast Elc1 plays an important role in global genomic repair but not in transcription coupled repair. DNA Repair (Amst.) 8, 40-50
4. Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. Science 284, 455-61