InterPro domain: IPR039937

This entry includes sorting nexins SNX20 and SNX21. They are sorting nexins (SNX) that orchestrate membrane trafficking and signaling events required for the proper distribution of proteins within the endosomal network. They contain an N-terminal PX domain and a C-terminal PX-associated B (PXB) domain. Their structures have been determined [ 1 ]. SNX20 has been shown to direct subcellular distribution of PSGL-1, a mucin-like glycoprotein [ 2 ]. SNX21 has been shown to serve as a scaffold for the endosomal recruitment of huntingtin [ 3 ].

1. Structure and Membrane Binding Properties of the Endosomal Tetratricopeptide Repeat (TPR) Domain-containing Sorting Nexins SNX20 and SNX21. J. Biol. Chem. 290, 14504-17
2. SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1. Eur. J. Immunol. 38, 550-64
3. Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin. J. Cell. Sci.