InterPro domain: IPR039910

This entry includes proteins with a domain similar to that of bacterial surface antigen (D15) from Haemophilus influenzae. Proteins include:

• Outer membrane protein assembly factor BamA, which forms part of the outer membrane protein assembly complex involved in assembly and insertion of beta-barrel proteins into the outer membrane in Gram-negative bacteria [ 1 ].
• Sorting and assembly machinery component 50, which is required for the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes [ 2 , 3 ].
• Translocation and assembly module subunit TamA, which is a component of the translocation and assembly module (TAM) autotransporter assembly complex which translocates autotransporters across the outer membrane [ 4 ].
• Outer envelope protein 80, chloroplastic, for which knockout is embryonic lethal [ 5 ].
• Outer envelope protein 39, chloroplastic [ 6 ].
• Protein TOC75, chloroplastic (translocon at the outer envelope membrane of chloroplasts, 75 kD), which functions as a preprotein translocation channel during chloroplast import [ 7 ].

1. The reconstituted Escherichia coli Bam complex catalyzes multiple rounds of β-barrel assembly. Biochemistry 50, 7444-6
2. Sam50 functions in mitochondrial intermembrane space bridging and biogenesis of respiratory complexes. Mol. Cell. Biol. 32, 1173-88
3. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. PLoS ONE 10, e0120213
4. Discovery of an archetypal protein transport system in bacterial outer membranes. Nat. Struct. Mol. Biol. 19, 506-10, S1
5. The Omp85-related chloroplast outer envelope protein OEP80 is essential for viability in Arabidopsis. Plant Physiol. 148, 235-45
6. The outer membrane Omp85-like protein P39 influences metabolic homeostasis in mature Arabidopsis thaliana. Plant Biol (Stuttg) 20, 825-833