InterPro domain: IPR039907

RNA-binding protein NOB1 has a nuclear location [ 1 ] and contains a PIN domain and binds a single zinc ion. Budding yeast Nob1 is involved in proteasomal and 40S ribosomal subunit biogenesis [ 2 ]. It is also required for maturation of the small subunit ribosomal RNA by catalyzing cleavage at site D after export of the preribosomal subunit into the cytoplasm. Nob1 is also found in archaea, where it is manganese-dependent and also processes RNA-substrates [ 3 ]. This entry also includes VapC1 and VapC3. VapC1 is a toxic component and a ribonuclease of a toxin-antitoxin (TA) module [ 4 ].

1. Cloning, expression and characterization of the human NOB1 gene. Mol. Biol. Rep. 32, 185-9
2. Nob1p, a new essential protein, associates with the 26S proteasome of growing saccharomyces cerevisiae cells. Gene 243, 37-45
3. Structural and functional analysis of the archaeal endonuclease Nob1. Nucleic Acids Res. 40, 3259-74
4. Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site. PLoS ONE 9, e112921