InterPro domain: IPR039905
General Information
- Identifier IPR039905
- Description CD2 antigen cytoplasmic tail-binding protein 2/Lin1
- Number of genes 136
- Gene duplication stats Loading...
- Associated GO terms GO:0005682
Abstract
CD2BP2, also known as U5-52K or LIN1, is a component of the U5 snRNP complex and acts as a splicing factor [ 1 , 2 ]. It also may play a role in the immune response as CD2 receptor binding protein 2 (CD2BP2) [ 3 ]. Lin1 from Saccharomyces cerevisiae is a non-essential component of U5 snRNP [ 4 ]; it may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication [ 5 ].
1. The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation. RNA 11, 598-608
2. The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function. J Mol Cell Biol 7, 402-14
3. Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2). J. Mol. Biol. 369, 902-8
4. Proteins interacting with Lin 1p, a putative link between chromosome segregation, mRNA splicing and DNA replication in Saccharomyces cerevisiae. Yeast 19, 1323-33