InterPro domain: IPR039901
General Information
- Identifier IPR039901
- Description 3-deoxy-D-manno-octulosonic acid transferase
- Number of genes 115
- Gene duplication stats Loading...
- Associated GO terms GO:0016740
Abstract
The proteins in this family are found mainly in bacteria and plants. In bacteria, 3-deoxy-D-manno-octulosonic acid (Kdo) transferase is involved in lipopolysaccharide synthesis; it catalyzes the transfer of two Kdo residues from CMP-Kdo to lipid IV(A), the precursor of lipid A [ 1 , 2 ]. In plants it is though to be involved in the synthesis of a mitochondrial lipid A-like molecule [ 3 ].
1. Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli. J. Biol. Chem. 267, 9988-97
2. Comparative analyses of secondary gene products of 3-deoxy-D-manno-oct-2-ulosonic acid transferases from Chlamydiaceae in Escherichia coli K-12. Eur. J. Biochem. 267, 5458-65
3. Characterization of a putative 3-deoxy-D-manno-2-octulosonic acid (Kdo) transferase gene from Arabidopsis thaliana. Glycobiology 20, 617-28