InterPro domain: IPR039869

This entry represents a group of ubiquitin domain-containing proteins, including UBTD1 and UBTD2. UBTD1 regulates cellular senescence through a positive feedback loop with TP53 [ 1 ]. UBTD1 and UBE2D (E2 ubiquitin conjugating enzyme) have been shown to form a stable, stoichiometric complex [ 2 ]. UBTD2, also known as DC-UbP, interacts with deubiquitinating enzyme USP5 and the Ub-activating enzyme UbE1 [ 3 ].

1. UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop. J. Pathol. 235, 656-67
2. The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. Biochem. Biophys. Res. Commun. 443, 7-12
3. A ubiquitin shuttle DC-UbP/UBTD2 reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes. PLoS ONE 9, e107509