InterPro domain: IPR039867
General Information
- Identifier IPR039867
- Description Protein furry/Tao3/Mor2
- Number of genes 197
- Gene duplication stats Loading...
- Associated GO terms GO:0000902
Abstract
This entry includes protein furry (fry) from animals, Tao3 (also known as Pag1) from budding yeasts and Mor2 from fission yeasts. Protein furry is involved in the Trc/fry signaling pathway and plays a key role in maintaining the integrity of polarized cell extensions (arista) during morphogenesis [ 1 ]. Tao3 is part of the the RAM signaling network involved in regulation of cellular morphogenesis [ 2 ]. Mor2 is also involved in the cell morphogenesis [ 3 ].
1. The furry gene of Drosophila is important for maintaining the integrity of cellular extensions during morphogenesis. Development 128, 2793-802
2. RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Mol. Biol. Cell 14, 3782-803
3. Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G(2) delay. EMBO J. 21, 4863-74