InterPro domain: IPR039865
General Information
- Identifier IPR039865
- Description Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
- Number of genes 150
- Gene duplication stats Loading...
- Associated GO terms GO:0035303
Abstract
PPP2R3C is a B'' family member and a regulatory B subunit of PP2A. It is also a subunit of the PP5/PPP2R3C complex. Both PP2A and PP5 are serine/threonine specific phosphatases. The PP5/PPP2R3C complex dephosphorylates P-glycoprotein/ABCB1 and down-regulates its expression and function [ 1 ]. This entry also includes TONNEAU2/FASS from Arabidopsis. TONNEAU2 is the B'' subunit of protein phosphatase 2A that regulates interphase microtubule nucleation [ 2 ].
Protein phosphatase 2A (PP2A) forms several holoenzyme complexes. The core enzyme consists of a catalytic C subunit (PP2Ac) and a regulatory A subunit (PR65) that is associated with a regulatory B subunit. The regulatory B subunit can be classified as a member of the B, B' or B'' families [ 3 ].
1. Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function. Cancer Lett. 345, 124-31
2. TONNEAU2/FASS regulates the geometry of microtubule nucleation and cortical array organization in interphase Arabidopsis cells. Plant Cell 24, 1158-70
3. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353, 417-39