InterPro domain: IPR039856

ER membrane protein complex subunit 2 (EMC2, also known as tetratricopeptide repeat protein 35) is a tetratricopeptide repeat-containing protein, and a component of the ER membrane protein complex (EMC), which is required for efficient folding of proteins in the endoplasmic reticulum (ER) [ 1 ]. This entry also includes TPR repeat protein Oca3 from the fission yeast Schizosaccharomyces pombe which may be involved in cell cycle regulation [ 2 ].

1. Defining human ERAD networks through an integrative mapping strategy. Nat. Cell Biol. 14, 93-105
2. Genome-wide search of Schizosaccharomyces pombe genes causing overexpression-mediated cell cycle defects. Yeast 19, 1139-51