InterPro domain: IPR039856
General Information
- Identifier IPR039856
- Description ER membrane protein complex subunit 2-like
- Number of genes 155
- Gene duplication stats Loading...
Abstract
ER membrane protein complex subunit 2 (EMC2, also known as tetratricopeptide repeat protein 35) is a tetratricopeptide repeat-containing protein, and a component of the ER membrane protein complex (EMC), which is required for efficient folding of proteins in the endoplasmic reticulum (ER) [ 1 ]. This entry also includes TPR repeat protein Oca3 from the fission yeast Schizosaccharomyces pombe which may be involved in cell cycle regulation [ 2 ].
1. Defining human ERAD networks through an integrative mapping strategy. Nat. Cell Biol. 14, 93-105
2. Genome-wide search of Schizosaccharomyces pombe genes causing overexpression-mediated cell cycle defects. Yeast 19, 1139-51
Species distribution
Gene table
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