InterPro domain: IPR039812

General Information

  • Identifier IPR039812
  • Description Vesicle-fusing ATPase
  • Number of genes 263
  • Gene duplication stats Loading...
  • Associated GO terms GO:0016887   GO:0035494  

Abstract

This family of vesicle-fusing ATPases includes NSF, an essential protein in membrane fusion events. NSF plays the role of a chaperone by activating SNAP receptor proteins (SNAREs) so that they can participate in membrane fusion. For subsequent rounds of fusion, the SNARE complex must be disassembled, and NSF, in conjunction with SNAPs, utilises its intrinsic ATPase activity to provide a driving force that disassembles SNARE complexes [ 1 , 2 , 3 ].


1. N-ethylmaleimide sensitive factor (NSF) structure and function. Int. Rev. Cytol. 207, 71-112
2. Mechanisms of synaptic vesicle exocytosis. Annu. Rev. Cell Dev. Biol. 16, 19-49
3. Disassembly of all SNARE complexes by N-ethylmaleimide-sensitive factor (NSF) is initiated by a conserved 1:1 interaction between α-soluble NSF attachment protein (SNAP) and SNARE complex. J. Biol. Chem. 288, 24984-91

Species distribution

Gene table