InterPro domain: IPR039796

General Information

  • Identifier IPR039796
  • Description MIP18 family
  • Number of genes 288
  • Gene duplication stats Loading...
  • Associated GO terms GO:0106035  

Abstract

MIP18 is a component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins [ 1 , 2 , 3 ]. This entry includes MIP18 and its homologues, such as YHR122W from S. cerevisiae [ 4 ] and AE7 from plants [ 5 ].


1. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. Cell Metab. 18, 187-98
2. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. Science 337, 195-9
3. MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Science 337, 243-5
4. Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol. Cell 30, 248-58
5. The DUF59 family gene AE7 acts in the cytosolic iron-sulfur cluster assembly pathway to maintain nuclear genome integrity in Arabidopsis. Plant Cell 24, 4135-48

Species distribution

Gene table