InterPro domain: IPR039733

The N-end rule pathway is an ubiquitin (Ub)-dependent proteolytic system that mediates and regulates the degradation of intracellular proteins through the recognition of their N-terminal residues. NTAQ1 (also known as Nta1 in fungi) is an N-terminal amidohydrolase, which converts N-terminal Asn and Gln to the N-terminal residues Asp and Glu, the first step of the hierarchically organized N-end rule pathway [ 1 ]. The structure of Nta1 has been determined [ 2 ].

1. Glutamine-specific N-terminal amidase, a component of the N-end rule pathway. Mol. Cell 34, 686-95
2. Structural basis for dual specificity of yeast N-terminal amidase in the N-end rule pathway. Proc. Natl. Acad. Sci. U.S.A. 113, 12438-12443