InterPro domain: IPR039731
General Information
- Identifier IPR039731
- Description CAAX prenyl protease 2, eukaryotes
- Number of genes 129
- Gene duplication stats Loading...
- Associated GO terms GO:0071586 GO:0030176 GO:0004222
Abstract
Rce1 is an integral membrane, metal-dependent endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins, such as Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatase [ 1 ]. It is classified as type II CAAX prenyl protease [ 2 , 3 ] and is included in peptidase family M79. Its structure has been solved [ 4 ].
1. Rce1: mechanism and inhibition. Crit. Rev. Biochem. Mol. Biol. 53, 157-174
2. Human ras-converting enzyme (hRCE1) endoproteolytic activity on K-ras-derived peptides. Anal. Biochem. 286, 129-37
3. The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities. Mol. Cell. Biol. 20, 4381-92
4. Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1. Nature 504, 301-5