InterPro domain: IPR039693

This entry includes Rtr1/2 from budding yeasts and its homologues, including RPAP2 from humans. Homologues are known from animals, plants and fungi. Rtr1 and Rtr2 are paralogues. Rtr1 is a RNA polymerase II (RNAPII)-binding protein. It is responsible for the transition of PolII into the elongation and termination phases of transcription by removing RNAPII CTD serine 5 phosphorylation (Ser5-P) at a selection of target genes [ 1 , 2 ].

Human RPAP2 is a CTD phosphatase that interacts directly with the RNA polymerase II subunit Rpb6 and participates in pre-mRNA 3'-end formation [ 3 ].

1. Rtr1 is a CTD phosphatase that regulates RNA polymerase II during the transition from serine 5 to serine 2 phosphorylation. Mol. Cell 34, 168-78
2. Phosphatase Rtr1 Regulates Global Levels of Serine 5 RNA Polymerase II C-Terminal Domain Phosphorylation and Cotranscriptional Histone Methylation. Mol. Cell. Biol. 36, 2236-45
3. Human RNA polymerase II-associated protein 2 (RPAP2) interacts directly with the RNA polymerase II subunit Rpb6 and participates in pre-mRNA 3'-end formation. Drug Discov Ther 8, 255-61