InterPro domain: IPR039682

General Information

  • Identifier IPR039682
  • Description Exocyst complex component Sec8/EXOC4
  • Number of genes 175
  • Gene duplication stats Loading...
  • Associated GO terms GO:0090522   GO:0000145  

Abstract

This entry includes Sec8 from fungi and EXOC4 from animals. Sec8 is a component of the exocyst complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane [ 1 ]. In fission yeasts, the exocyst complex is also required for polarized cell growth and division septum assembly [ 2 ]. EXOC4 has been shown to regulate N-cadherin expression by controlling Smad3 and Smad4 expression through CREB binding protein, thereby mediating the epithelial-mesenchymal transition and early embryonic development [ 3 ].


1. The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J. 15, 6483-94
2. Role of septins and the exocyst complex in the function of hydrolytic enzymes responsible for fission yeast cell separation. Mol. Biol. Cell 16, 4867-81
3. Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4. Cell. Signal. 29, 115-126

Species distribution

Gene table