InterPro domain: IPR039653

This entry includes various prenyltransferases, including:

• 4-hydroxybenzoate octaprenyltransferase (ubiA) catalyses the prenylation of para-hydroxybenzoate, a step in the biosynthesis of ubiquinone-8 [ 1 ].
• mitochondrial 4-hydroxybenzoate polyprenyltransferase catalyses the prenylation of para-hydroxybenzoate, a step in the biosynthesis of coenzyme Q [ 2 ].
• Decaprenyl-phosphate phosphoribosyltransferase transfers a 5-phosphoribosyl residue from phosphoribose diphosphate to decaprenyl phosphateto form decaprenylphosphoryl-5-phosphoribose, a step in the biosynthesis of decaprenylphosphoryl arabinose, a precursor of a component required for mycobacterial cell wall biosynthesis [ 3 ].
• 4-hydroxybenzoate geranyltransferases 1 and 2 required for the biosynthesis of shikonin, a naphthoquinone secondary metabolite in plants [ 4 ].
• 4-hydroxybenzoate solanesyltransferase prenylates para-hydroxybenzoate during plastoquinone-9 biosynthesis [ 5 ].

1. Characterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli. Biochim. Biophys. Acta 1212, 93-102
2. Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ. Biochem. J. 382, 519-26
3. Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-{alpha}-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesis. J. Biol. Chem. 280, 24539-43
4. Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis. J. Biol. Chem. 277, 6240-6
5. Plastoquinone-9 biosynthesis in cyanobacteria differs from that in plants and involves a novel 4-hydroxybenzoate solanesyltransferase. Biochem. J. 442, 621-9