InterPro domain: IPR039644
General Information
- Identifier IPR039644
- Description High osmolarity signalling protein Sho1
- Number of genes 1
- Gene duplication stats Loading...
- Associated GO terms GO:0005034
Abstract
Sho1 is a yeast membrane protein that regulates adaptation to high salt conditions by activating the HOG (high-osmolarity glycerol) pathway [ 1 ]. High salt concentrations lead to the localization to the membrane of the MAPKK Pbs2, which is then activated by the MAPKKK Ste11 and in turn, activates the MAPK Hog1 [ 2 , 3 ]. Pbs2 is localized to the membrane though the interaction of its PxxP motif with the SH3 domain of Sho1 [ 4 , 4 ].
1. Automated ensemble modeling with modelMaGe: analyzing feedback mechanisms in the Sho1 branch of the HOG pathway. PLoS ONE 6, e14791
2. MAPK signaling: Sho business. Curr. Biol. 14, R708-10
3. Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway. EMBO J. 25, 3033-44
4. Sho1 and Pbs2 act as coscaffolds linking components in the yeast high osmolarity MAP kinase pathway. Mol. Cell 14, 825-32