InterPro domain: IPR039620

MAKRs belong to the MEMBRANE-ASSOCIATED KINASE REGULATOR (MAKR) family, whose members contain putative kinase interacting motifs and membrane localization signals [ 1 , 2 ].

This entry represents a group of plant proteins, including BKI1 and MAKR1/3/4 from Arabidopsis. BKI1 interacts with BRI1, a leucine-rich repeat receptor serine/threonine kinase, and prevents the activation of BRI1 [ 3 ].

1. Tyrosine phosphorylation controls brassinosteroid receptor activation by triggering membrane release of its kinase inhibitor. Genes Dev. 25, 232-7
2. A PtdIns(4)P-driven electrostatic field controls cell membrane identity and signalling in plants. Nat Plants 2, 16089
3. Brassinosteroids regulate dissociation of BKI1, a negative regulator of BRI1 signaling, from the plasma membrane. Science 313, 1118-22