InterPro domain: IPR039609

In general, Arabidopsis VQPs interacted specifically with the C-terminal WRKY domains of group I and the sole WRKY domains of group IIc WRKY transcription factors [ 1 , 2 ]. Arabidopsis VQPs reported to control stress responses include the calmodulin (CaM)-binding protein CamBP25 and VQ9, which regulate osmotic and salinity tolerance, respectively, the sigma factor binding proteins SIB1 and SIB2, which act as activators of WRKY33 in plant defence, and the negative regulator of the jasmonate defence pathway [ 3 ].

This entry includes a group of VQ motif-containing proteins from plants, including VQ15/22 from Arabidopsis. VQ15, also known as calmodulin-binding protein 25, can work as a negative regulator of osmotic stress tolerance [ 4 ].

1. Structural and functional analysis of VQ motif-containing proteins in Arabidopsis as interacting proteins of WRKY transcription factors. Plant Physiol. 159, 810-25
2. The VQ Motif-Containing Protein Family of Plant-Specific Transcriptional Regulators. Plant Physiol. 169, 371-8
3. The Arabidopsis thaliana mitogen-activated protein kinases MPK3 and MPK6 target a subclass of 'VQ-motif'-containing proteins to regulate immune responses. New Phytol. 203, 592-606
4. A novel calmodulin-binding protein functions as a negative regulator of osmotic stress tolerance in Arabidopsis thaliana seedlings. Plant J. 38, 410-20