InterPro domain: IPR039562

This entry represents the biotin-lipoyl like domain found in some bacterial membrane fusion proteins, such as AaeA and MdtA. AaeA is part of the efflux AaeAB pump [ 1 ], while MdtA is part of the MdtABC tripartite complex that confers resistance against novobiocin and deoxycholate [ 2 ].

MFPs are a component of the RND family of transporters (RND refers to resistance, nodulation, and cell division). MFPs are proposed to span the periplasm in some way linking the inner and outer membranes [ 3 ]. However, some members of this family are found in Gram-positive bacteria, where there is no outer membrane. MFPs are involved in the export of a variety of compounds, from drug molecules to large polypeptides, and are united by their similar overall structural organisation, combined with some conserved regions [ 4 ].

1. Characterization of the Escherichia coli AaeAB efflux pump: a metabolic relief valve? J. Bacteriol. 186, 7196-204
2. The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC. J. Bacteriol. 184, 4161-7
3. A topological model for the haemolysin translocator protein HlyD. Mol. Gen. Genet. 234, 155-63
4. Mutations in HlyD, part of the type 1 translocator for hemolysin secretion, affect the folding of the secreted toxin. J. Bacteriol. 187, 7471-80