InterPro domain: IPR039543

This entry includes poorly characterised, lipid-binding proteins containing an SCP2 sterol-binding domain. Non-specific lipid-transfer protein-like 1 (NSL-TP1 or nlt-1) from Caenorhabditis elegans is found in the peroxisome. Protein UbiT (also known as YhbT) from Escherichia coli is cytosolic. The oleate-induced peroxisomal protein POX18 from the yeast Candida tropicalis , which is involved in beta-oxidation of long-chain fatty acids and nonspecific lipid-transfer activity, despite not having the catalytic cysteine conserved [ 1 ]. In vitro Arabidopsis thaliana SCP2 (AtSCP2) has been shown to enhance the transfer of lipids between membranes [ 2 ] and is localised in the peroxisome [ 3 ].

1. A novel peroxisomal nonspecific lipid-transfer protein from Candida tropicalis. Gene structure, purification and possible role in beta-oxidation. Eur. J. Biochem. 190, 107-12
2. Arabidopsis sterol carrier protein-2 is required for normal development of seeds and seedlings. J. Exp. Bot. 59, 3485-99
3. Plants express a lipid transfer protein with high similarity to mammalian sterol carrier protein-2. J. Biol. Chem. 279, 53544-53