InterPro domain: IPR039481
General Information
- Identifier IPR039481
- Description Exocyst complex component EXOC2/Sec5, N-terminal domain
- Number of genes 155
- Gene duplication stats Loading...
Abstract
This entry represent a domain found in N terminus of Sec5 from budding yeasts and EXOC2 from animals.
In S. cerevisiae, Sec5 is an essential component of the exocyst complex, which is composed of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70 and Exo84 [ 1 ]. The exocyst complex tethers post-Golgi secretory vesicles to the plasma membrane before soluble NSF attachment protein receptor (SNARE)-mediated membrane fusion [ 2 ].
In mammals, active form (GTP-bound) of Ral GTPase interacts with EXOC2 and Exo84 and regulates the assembly interface of a full octameric exocyst complex [ 3 ]. Similar to yeast exocyst, the mammalian exocyst has been directly linked to post-Golgi targeting of secretory vesicles to discreet membrane sites [ 4 ].
1. Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. J. Cell Biol. 130, 299-312
2. The exocyst complex in exocytosis and cell migration. Protoplasma 249, 587-97
3. Ral GTPases regulate exocyst assembly through dual subunit interactions. J. Biol. Chem. 278, 51743-8