InterPro domain: IPR039431

This domain can be found in the N terminus of the Vta1 protein, which is a class E vacuolar protein sorting (VPS) protein required for the formation of the multivesicular body (MVB) [ 1 ]. Proteins containing this domain also include Vta1 homologues, such as SBP1 from humans and LIP5 from Arabidopsis thaliana [ 2 ]. This domain can also be found in plant callose synthase, which is involved in callose synthesis at the forming cell plate during cytokinesis [ 3 ].

1. Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae. J. Biol. Chem. 279, 10982-90
2. Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1. J. Cell Biol. 172, 705-17
3. A cell plate-specific callose synthase and its interaction with phragmoplastin. Plant Cell 13, 755-68