InterPro domain: IPR039399

The deltex family of proteins is involved in the regulation of Notch signaling, and therefore may play roles in cell-to-cell communications that regulate mechanisms determining cell fate [ 1 ]. They have a central RING-type zinc finger domain and contain a C-terminal domain that is also found in other domain architectures. Deltex-1 (DTX1) contains a RING finger and two WWE domains, indicating that it may be an E3 ubiquitin ligase [ 2 ]. Human deltex 3-like, which contains an additional N-terminal domain (presumably with ubiquitin ligase activity) is also described as E3 ubiquitin-protein ligase DTX3L, B-lymphoma- and BAL-associated protein (BBAP), or rhysin-2. DTX3L mediates monoubiquitination of K91 of histone H4 in response to DNA damage [ 3 , 4 ].

This entry represents the C-terminal domain of the Deltex proteins. It contains a fold composed of central beta-sheet lined with two long parallel alpha-helices [ 5 ].

1. Human deltex is a conserved regulator of Notch signalling. Nat. Genet. 19, 74-8
2. Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness. Oncogene 29, 2916-26
3. Fold of the conserved DTC domain in Deltex proteins. Proteins 80, 1495-9
4. The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. J. Biol. Chem. 278, 21930-7