InterPro domain: IPR039390

Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form 3-hydroxy-cis,cis-muconates. 1,2-HQD belongs to the aromatic dioxygenase family, a family of mononuclear non-heme intradiol-cleaving enzymes. It can act on catechol, but its activity for hydroxyquinol is 6.8-fold higher [ 1 , 2 , 3 ].

This family also includes eukaryotic catechol 1,2-dioxygenase [ 4 ].

1. Catechol dioxygenases. Essays Biochem. 34, 173-89
2. Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E, a key enzyme involved in polychlorinated aromatics biodegradation. J. Biol. Chem. 280, 21144-54
3. Biodegradation of 2,4,5-trichlorophenoxyacetic acid by Burkholderia cepacia strain AC1100: evolutionary insight. Gene 179, 1-8
4. Purification and characterization of a catechol 1,2-dioxygenase from a phenol degrading Candida albicans TL3. Arch. Microbiol. 187, 199-206