InterPro domain: IPR039337

This entry represents a group of plant proteins, including GLV2 (also known as RGF9) from Arabidopsis. GLV2 is a signaling peptide (root growth factor) that regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells [ 1 , 2 ]. It is also involved in the regulation of hypocotyl bending and root gravitropism, probably by influencing the formation of auxin gradients [ 3 ]. In general, RGFs are required for maintenance of the root stem cell niche and transit amplifying cell proliferation in Arabidopsis [ 4 ].

1. CLE-like (CLEL) peptides control the pattern of root growth and lateral root development in Arabidopsis. Proc Natl Acad Sci U S A 109, 1760-5
2. Transcriptional and functional classification of the GOLVEN/ROOT GROWTH FACTOR/CLE-like signaling peptides reveals their role in lateral root and hair formation. Plant Physiol 161, 954-70
3. GOLVEN secretory peptides regulate auxin carrier turnover during plant gravitropic responses. Dev Cell 22, 678-85
4. Secreted peptide signals required for maintenance of root stem cell niche in Arabidopsis. Science 329, 1065-7