InterPro domain: IPR039331
General Information
- Identifier IPR039331
- Description Purple acid phosphatase-like
- Number of genes 1529
- Gene duplication stats Loading...
- Associated GO terms GO:0003993
Abstract
Purple acid phosphatases ( 3.1.3.2 ) are a family of binuclear metallohydrolases that have been identified in plants, animals and fungi. The best characterized enzyme is from kidney bean, and that enzyme binds Fe 3+ and Zn 2+ ions. The metals bound differ according to source species, for example the enzyme from sweet potato binds iron and manganese [ 1 ]. The structure of the kidney bean enzyme has been solved, and shows a disulfide-linked homodimer, with each monomer having a two-domain structure [ 2 ]. Human acid phosphatase type 7 is also known as purple acid phosphatase long form. It is associated with bone resorption and microbial killing through its phosphatase activity, and hydroxyl radical production [ 3 ].
1. Binuclear metal centers in plant purple acid phosphatases: Fe-Mn in sweet potato and Fe-Zn in soybean. Arch. Biochem. Biophys. 370, 183-9
2. Crystal structure of a purple acid phosphatase containing a dinuclear Fe(III)-Zn(II) active site. Science 268, 1489-92
3. Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. Gene 377, 12-20