InterPro domain: IPR039314

This entry includes CP12, a chloroplast protein that regulates the Calvin cycle responsible for CO2 assimilation [ 1 ]. Oxidized CP12 forms a supramolecular complex with two key Calvin cycle enzymes, GAPDH (glyceraldehyde-3-phosphate dehydrogenase) and PRK (phosphoribulokinase), down-regulating their activity. It also interacts with other enzymes such as aldolase and malate dehydrogenase [ 2 ]. This entry also includes proteins from Cyanobacteria (blue-green algae).

1. The small protein CP12: a protein linker for supramolecular complex assembly. Biochemistry 42, 8163-70
2. An intrinsically disordered protein, CP12: jack of all trades and master of the Calvin cycle. Biochem. Soc. Trans. 40, 995-9