InterPro domain: IPR039301

This entry includes a group of fungal and plant proteins, including Sip5 from budding yeasts and DA2 from Arabidopsis. The function of Sip5 is not clear. It interacts with both the Reg1/Glc7 protein phosphatase and the Snf1 protein kinase [ 1 ].

DA2 (At1g78420) is an E3 ubiquitin-protein ligase involved in the regulation of organ and seed size [ 2 , 3 ]. This entry also includes DA2-like proteins such as At1g17145 and GW2 [ 4 ].

1. Sip5 interacts with both the Reg1/Glc7 protein phosphatase and the Snf1 protein kinase of Saccharomyces cerevisiae. Genetics 154, 99-107
2. The ubiquitin receptor DA1 interacts with the E3 ubiquitin ligase DA2 to regulate seed and organ size in Arabidopsis. Plant Cell 25, 3347-59
3. Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis. Genes Dev. 31, 197-208
4. A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase. Nat. Genet. 39, 623-30