InterPro domain: IPR039272

CLEC16A (C-Type Lectin Domain Containing 16A) has an inhibitory role in autophagy, probably by activating the mTOR pathway [ 1 ]. It also has a role in beta-cells as a regulator of mitophagy [ 2 ].

GFS9/TT9 (TRANSPARENT TESTA 9) is a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles. It contributes to intracellular membrane trafficking and flavonoid accumulation [ 3 ].

1. Human CLEC16A regulates autophagy through modulating mTOR activity. Exp. Cell Res. 352, 304-312
2. The diabetes susceptibility gene Clec16a regulates mitophagy. Cell 157, 1577-90
3. GFS9/TT9 contributes to intracellular membrane trafficking and flavonoid accumulation in Arabidopsis thaliana. Plant J. 80, 410-23