InterPro domain: IPR039262
General Information
- Identifier IPR039262
- Description DTW domain-containing protein DTWD2/YfiP
- Number of genes 324
- Gene duplication stats Loading...
Abstract
Proteins in this entry contain a DTW domain (with the presence of a central DTXW motif). DTW domain containing protein may have a SAM-dependent acp transferase activity [ 1 ]. This entry includes DTWD2, also known as tRNA-uridine aminocarboxypropyltransferase 2, from humans and YfiP (also known as TapT) from Escherichia coli. YfiP is a tRNA-uridine aminocarboxypropyltransferase that catalyses the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 47 of tRNAs [ 2 , 3 ].
1. Identification of the 3-amino-3-carboxypropyl (acp) transferase enzyme responsible for acp3U formation at position 47 in Escherichia coli tRNAs. Nucleic Acids Res. 48, 1435-1450
2. Biogenesis and functions of aminocarboxypropyluridine in tRNA. Nat Commun 10, 5542