InterPro domain: IPR039253
General Information
- Identifier IPR039253
- Description Aprataxin and PNK-like factor
- Number of genes 4
- Gene duplication stats Loading...
- Associated GO terms GO:0008408 GO:0003906 GO:0006302
Abstract
The protein APLF (aprataxin and PNK-like factor or Xip1; 4.2.99.18 ) is a nuclease involved in single-strand and double-strand DNA break repair [ 1 ]. It has endo- and exonuclease activities and contains a FHA (forkhead-associated) domain and zinc-finger-like CYR motifs [ 2 ]. APLF interacts with XRCC1 and XRCC4 via its FHA domain [ 3 , 4 ].
1. Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks. J. Biol. Chem. 282, 19638-43
2. A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. EMBO J. 26, 2094-103
3. APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. Mol. Cell. Biol. 27, 3793-803
4. APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation. DNA Repair (Amst.) 7, 292-302