InterPro domain: IPR039223

Apoptosis antagonizing transcription factor (AATF, also known as Che-1) is a adaptor that connects transcriptional regulation, cell-cycle progression, checkpoint control, and apoptosis [ 1 ]. It contains a leucine zipper-containing domain [ 2 ]. AATF has been shown to inhibit the aberrant production of the amyloid beta peptide 1-42 by direct interaction with Par4; this interaction occurs via the leucine zipper. [ 3 ]. AATF has also been shown to form a nucleolar protein complex with NGDN and NOL10 required for 40S ribosomal subunit synthesis [ 4 ].

This entry also includes the yeast protein Bfr2, which is a component of the SSU processome and 90S preribosomes [ 5 ].

1. Che-1/AATF, a multivalent adaptor connecting transcriptional regulation, checkpoint control, and apoptosis. Biochem. Cell Biol. 85, 477-83
2. Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb. Cancer Cell 2, 387-99
3. AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4. J. Biol. Chem. 279, 4596-603
4. Human AATF/Che-1 forms a nucleolar protein complex with NGDN and NOL10 required for 40S ribosomal subunit synthesis. Nucleic Acids Res. 44, 9803-9820
5. Nucleolar proteins Bfr2 and Enp2 interact with DEAD-box RNA helicase Dbp4 in two different complexes. Nucleic Acids Res. 42, 3194-206