InterPro domain: IPR039215

RecQ-mediated genome instability protein 1 (RMI1 or BLAP75) is a component of the RMI complex. The RMI complex contains the helicase BLM, which is mutated in Bloom's disease, a rare human genetic disorder characterized by dwarfism, immunodeficiency, genomic instability and cancer predisposition [ 1 ]. The complex is a dissolvasome that processes homologous recombination intermediates to limit DNA crossover formation, specifically dissolving the double Holliday junction to yield non-crossover recombinants [ 2 ]. RMI1 contains a OB-fold nucleic acid binding domain [ 3 ] and promotes dissolution catalyzed by another component of the RMI complex, topoisomerase IIIalpha [ 3 ].

1. BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity. EMBO J. 24, 1465-76
2. A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75. J. Biol. Chem. 281, 13861-4
3. BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates. Proc. Natl. Acad. Sci. U.S.A. 103, 4068-73