InterPro domain: IPR039188

General Information

  • Identifier IPR039188
  • Description ATPase family AAA domain-containing protein 3
  • Number of genes 332
  • Gene duplication stats Loading...
  • Associated GO terms GO:0005739   GO:0007005  

Abstract

This entry represents ATAD3 and its homologues, including ATAD3A/B/C from humans. They play an important role in mitochondrial network organization [ 1 ]. ATAD3 contains two N-terminal coiled-coil domains, a central trans-membrane segment and a conserved C-terminal ATPase domain of the AAA+-type with an ATP-binding (Walker A motif) and a catalytic ATPase domain (Walker B motif) [ 2 ].

ATAD-3 is necessary for Caenorhabditis elegans larval development and is essential for the progression of the first steps of post-implantation development in mice [ 3 , 3 ].


1. C. elegans ATAD-3 is essential for mitochondrial activity and development. PLoS ONE 4, e7644
2. The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes. Mol. Cell. Biol. 30, 1984-96
3. Atad3 function is essential for early post-implantation development in the mouse. PLoS ONE 8, e54799

Species distribution

Gene table