InterPro domain: IPR039187

Strawberry notch proteins carry DExD/H-box groups and helicase C-terminal domains. These proteins promote the expression of diverse targets, potentially through interactions with transcriptional activator or repressor complexes [ 1 ]. Strawberry notch was first identified in Drosophila where functions downstream of Notch and regulates gene expression during development [ 2 , 3 ].

This entry represents the AAA domain found in Strawberry notch protein.

1. A strawberry notch homolog, let-765/nsh-1, positively regulates lin-3/egf expression to promote RAS-dependent vulval induction in C. elegans. Dev. Biol. 341, 472-85
2. strawberry notch encodes a conserved nuclear protein that functions downstream of Notch and regulates gene expression along the developing wing margin of Drosophila. Genes Dev. 11, 1341-53
3. Developmental signaling: shrimp and strawberries help flies make cones. Curr. Biol. 12, R722-4