InterPro domain: IPR039177

General Information

  • Identifier IPR039177
  • Description Protein SMG9
  • Number of genes 113
  • Gene duplication stats Loading...
  • Associated GO terms GO:0000184  

Abstract

Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that detects and degrades mRNAs containing premature translation termination codons. Protein SMG9 is a component of the SMG1C protein kinase complex (along with SMG1 and SMG8) which is recruited to stalled ribosomes. SMG8 and SMG9 suppress SMG1 kinase activity in the isolated SMG1 complex [ 1 ].


1. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev. 23, 1091-105

Species distribution

Gene table