InterPro domain: IPR039156

General Information

  • Identifier IPR039156
  • Description PHAF1/Protein broad-minded
  • Number of genes 136
  • Gene duplication stats Loading...

Abstract

This entry includes protein broad-minded, which interacts with cell cycle-related kinase (CCRK) and together these proteins regulate ciliary membrane and axonemal growth [ 1 ]; and phagosome assembly factor 1 (PHAF1) and its homologues. PHAF1 and BCAS3 form a complex that affects the recruitment of several core autophagy proteins to the phagophore assembly site [ 2 ].


1. Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev. Cell 18, 237-47
2. Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy. Autophagy , 1-26

Species distribution

Gene table

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