InterPro domain: IPR039143
General Information
- Identifier IPR039143
- Description Glucosamine 6-phosphate N-acetyltransferase
- Number of genes 240
- Gene duplication stats Loading...
- Associated GO terms GO:0004343 GO:0006048
Abstract
Glucosamine 6-phosphate N-acetyltransferase (GNPNAT1; 2.3.1.4 ) is a component in the pathway for UDP-N-acetyl-alpha-D-glucosamine biosynthesis. GNPNAT1 transfers the acetyl group from acetyl-CoA to D-glucosamine 6-phosphate to generate N-acetyl-D-glucosamine 6-phosphate [ 1 ]. The enzyme contains a GNAT domain and is naturally a homodimer [ 2 ]. The enzyme from Aspergillus fumigatus , the causative agent of aspergillosis, is a potential drug target [ 2 ].
1. Acceptor substrate binding revealed by crystal structure of human glucosamine-6-phosphate N-acetyltransferase 1. FEBS Lett. 582, 2973-8
2. Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase. Biochem. J. 415, 217-23
Species distribution
Gene table
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