InterPro domain: IPR039143

General Information

  • Identifier IPR039143
  • Description Glucosamine 6-phosphate N-acetyltransferase
  • Number of genes 240
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004343   GO:0006048  

Abstract

Glucosamine 6-phosphate N-acetyltransferase (GNPNAT1; 2.3.1.4 ) is a component in the pathway for UDP-N-acetyl-alpha-D-glucosamine biosynthesis. GNPNAT1 transfers the acetyl group from acetyl-CoA to D-glucosamine 6-phosphate to generate N-acetyl-D-glucosamine 6-phosphate [ 1 ]. The enzyme contains a GNAT domain and is naturally a homodimer [ 2 ]. The enzyme from Aspergillus fumigatus , the causative agent of aspergillosis, is a potential drug target [ 2 ].


1. Acceptor substrate binding revealed by crystal structure of human glucosamine-6-phosphate N-acetyltransferase 1. FEBS Lett. 582, 2973-8
2. Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase. Biochem. J. 415, 217-23

Species distribution

Gene table