InterPro domain: IPR039135

This entry includes acetyltransferases such as N-acetyltransferase 9 (NAT9). The NAT9 gene is an important reproduction related gene and is associated with psoriatic arthritis [ 1 ] and possibly with Crohn's disease [ 2 ]. NAT9 contains a GNAT domain.

FsC-acetyl coenzyme A-N(2)-transacetylase (sidG) from the yeast Neosartorya fumigata is a component of the siderophore biosynthetic pathway, catalyzing N2-acetylation of fusarinine C (FsC) to form triacetylfusarinine C (TAFC) [ 3 , 4 ]. Acetyltransferase PA3944 from Pseudomonas aeruginosa has been shown to catalyze the transfer of an acetyl group from acetyl coenzyme A to an acceptor substrate. PA3944 also has activity on aspartame and the peptide antibiotics polymyxin B and colistin [ 5 ].

1. Investigation of association of genes NAT9, SLC9A3R1 and RAPTOR on chromosome 17q25 with psoriatic arthritis. Ann. Rheum. Dis. 68, 292-3
2. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. Circ Cardiovasc Genet 2, 134-41
3. SidL, an Aspergillus fumigatus transacetylase involved in biosynthesis of the siderophores ferricrocin and hydroxyferricrocin. Appl. Environ. Microbiol. 77, 4959-66
4. Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. PLoS Pathog. 3, 1195-207
5. Broad-substrate screen as a tool to identify substrates for bacterial Gcn5-related N-acetyltransferases with unknown substrate specificity. Protein Sci. 22, 222-30