InterPro domain: IPR039133

General Information

  • Identifier IPR039133
  • Description E3 ubiquitin-protein ligase RNF25
  • Number of genes 108
  • Gene duplication stats Loading...
  • Associated GO terms GO:0061630  

Abstract

E3 ubiquitin-protein ligase RNF25 (also known as AO7) ubiquitinates NKD2, leading to its degradation by the proteasome [ 1 ]. It interacts with other Ub ligases [ 2 ].


1. EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. Proc. Natl. Acad. Sci. U.S.A. 105, 13433-8
2. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc. Natl. Acad. Sci. U.S.A. 96, 11364-9

Species distribution

Gene table